CARO-OL

unique and exclusive ingredient in the whole world with carob-tree and olive tree combined

CARO-OL is a synergic blend of medical plants containing carob fruit (Ceratonia siliqua) and polyphenol from olive tree leaves (Olea europaea).
CARO-OL is composed of carob fruit micronized rich in quercetin and catechins, olive tree leaves micronized and olive tree leaves extract titled of 40% oleuropein.
CARO-OL has different functions. It can be an antioxidant, an antimicrobial, a support to chemotherapy and is also neuroprotective.

Technical information

COMPOSITION: Ceratonia siliqua: 90 – 93% (W/W), Olea Europea micronized and leaf extract titled of 40% oleuropein: 5 – 7% (W/W), total polyphenols (HPLC/DAD): 2,7 – 2,5% (W/W)

ANTIOXIDANT ACTIVITY: Carob fruit – 8,26 mgGAE/g, CARO-OL 24,9 mgGAE/g

*CARO-OL has a major antioxidant activity compared with that of carob fruit alone.

SUGGESTED DOSAGE:: 250 – 500 mg/die.

USAGE: nutraceuticals and cosmetics.

Free radicals are the usual product of mitochondrial activity; in physiological conditions, there’s a balance between the production of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) and superoxide (O2-), and anti-oxidative substances found in our body, among which superoxide dismutase enzyme (SOD) and glutathione peroxidase enzyme (GPxs). The breaking of this balance increases ROS levels which leads to the oxidation of biological molecules such as lipids, proteins and DNA; therefore, the oxidative stress is defined as the imbalance between ROS levels and anti-oxidant enzymes that help to abolish ROS(Mitochondrial dysfunction and oxidative stress in aging and cancer, Anna V. Kudryavtseva et al., 2016).
Bacterial infections are the largest cause of death among children and immunocompromised patients. Bacteria can penetrate our body by skin injury or by air; once they are inside our body, bacteria create biofilm, they expand and communicate through Quorum sensing evading the immune response. The treatments we use are essential to achieve success; however, microorganisms often develop some form of resistance complicating the treatment. Herein, the use of some natural substances with anti-microbial powers gives advantages in the healing process.
Neurodegenerative diseases are age-related. From a pathophysiological point of view, they can affect both cognitive abilities and motor skills of patients. Several studies have shown the relevance of using natural compounds in the progression of neurodegenerative diseases. For example, oleuropein counteracts the formation of amyloid beta (Aβ) aggregates characteristic of Alzheimer’s disease.
Cancer is one of the most common disease in the world. So far the main pharmacological treatment of tumor is chemotherapy, which is the use of drugs to counteract tumor growth and metastasis. Some studies have shown that some natural compounds improve the activity of chemotherapy drugs by helping to inhibit tumor cells proliferation; moreover, some natural substances cause a decrease of side effects caused by the chemotherapy itself (Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates, Imran M. et al., 2018).

Quercetin

is a flavonoid present in different kinds of food such as carob tree, apples, berries and onions.

This compound is known for its anti-oxidant and antibacterial functions, since it blocks E. coli gyrase enzyme activity; quercetin is also an antiviral compound and different in vitro studies prove its efficacy: a 2018 study shows that quercetin counteracts Enterovirus71 (EV71) infection in RD (Human rhabdomyosarcoma cells) and Vero (African green monkey kidney cells) cells. It is also an anti-tumorigenic molecule because it modulates the cyclin activity; quercetin fulfills an anti-inflammatory function and a neuro-protective activity since it preserves neurons from the beta-amyloid toxicity.

Catechins

are natural polyphenol present in various foods and plants such as carob fruit, tea and cocoa.

The most aboundant catechins are epicatechin, epicatechin gallate and epigallate-catechin. This class of compound fulfills different functions among which an anti-oxidant activity: some studies show that catechins activate glutathion peroxidase and glutation leading to a decrease of oxidative stress in the colon. They also have an anti-inflammatory activity, since they adjust the pathways correlated with inflammation, such as NF-kB pathway, and they fulfill an anti-tumorigenic function, since they inhibit tumor cells proliferation and neo-angiogenesis by suppressing VEGF factor. Catechins also show a protective effect for atherosclerosis and they regulate the microbiota reducing inflammatory disease of the intestinal tract (IDB).

Oleuropein

is the major phenolic compound present in the olives tree, Olea europea L.

This molecule is composed by Elenolic Acid, Glucose and Idrossythyrosol; oleuropein is degradated by microflora and during this process its metabolite, hydrossythyrosol, is formed and it is absorbed in the intestine through a passive diffusion mechanism.
It is a substance well known for its antioxidant and anti-inflammatory effects. However it fulfills many other functions such as the anti-tumorigenic activity: the simultaneous treatment with oleuropein and doxorubicin has been proven to reduce the proliferative action of NF-kB and ciclin D1; it has a cardio-protective function because it reduces blood pressure in hypertenstive patient and, in vitro, it blocks platelet aggregation. It is also a neuro-protective molecules since it decreases the oxidative damage in the substantia nigra, a region of the brain affected by Parkinson’s disease; moreover, it prevents the formation of amyloid beta (Aβ) aggregates, characteristic of Alzheimer’s disease. Oleuropein has also an antibacterial function and an anti-diabetic activity since it helps decrease the blood glucose levels by contrasting insulin-resistance.

Our products are made exclusively with certified carob trees provided by the best farmers of the Hyblaean Coast, in Sicily, which can be considered the most suited Italian territory to cultivate such fascinating trees.

Our products only employ the leaves of organically grown olive trees from Tuscan hills, an Italian region with an extremely long-standing tradition of olive-growing.

To develop our extracts we follow safe, effective as well as environment- and use-friendly methods. Furthermore, we benefit of the valuable cooperation with the University of Florence.

Studies

  • Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates (Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Shaista Khan, Muhammad Wasim Sajid  and Rai Muhammad Amir)
  • Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases (Chiara Nediani, Jessica Ruzzolini, Annalisa Romani and Lido Calorini)
  • Oleuropein and Cancer Chemoprevention: The Link is Hot (Ammad Ahmad Farooqi, Sundas Fayyaz, Ana Sanches Silva, Antoni Sureda, Seyed Fazel Nabavi, Andrei Mocan, Seyed Mohammad Nabavi and Anupam Bishayee) 
  • Oleuropein, unexpected benefits!  (Wenyan Sun, Bess Frost and Jiankang Liu)
  • Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative E_ects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells (Samia S. Messeha, Najla O. Zarmouh, Abrar Asiri and Karam F. A. Soliman)
  • Cardioprotective and neuroprotective roles of oleuropein in olive (Syed Haris Omar)
  • Olea europaea: A Phyto-Pharmacological Review (Md. Yaseen Khan, Siddharth Panchal, Niraj Vyas, Amee Butani, Vimal Kumar)
  • Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling (Zhiwei Zhang, Hui Zhao, Aixia Wang)
  • Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry (WenjiaoWu, Richan Li, Xianglian Li, Jian He, Shibo Jiang, Shuwen Liu and Jie Yang)
  • Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More (Lucio G. Costa, Jacqueline M. Garrick, Pamela J. Roquè, and Claudia Pellacani)
  • Quercetin, Inflammation and Immunity (Yao Li, Jiaying Yao, Chunyan Han, Jiaxin Yang, Maria Tabassum Chaudhry, Shengnan Wang, Hongnan Liu and Yulong Yin)
  • Antimicrobial activity of flavonoids (T.P. Tim Cushnie, Andrew J. Lamb)
  • The Anti-Cancer E_ect of Quercetin: Molecular Implications in Cancer Metabolism (Marjorie Reyes-Farias and Catalina Carrasco-Pozo)
  • Inhibition of enterovirus 71 replication and viral 3C protease by quercetin (Chenguang Yao, Caili Xi, Kanghong Hu, Wa Gao, Xiaofeng Cai, Jinlan Qin, Shiyun Lv, Canghao Du and Yanhong Wei)
  • Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus (Parvaneh Mehrbod, Dorota Hudy, Divine Shyntum, Jarosław Markowski, Marek J. Łos  and Saeid Ghavami)
  • Quercetin-induced apoptosis prevents EBV infection (Minjung Lee, Myoungki Son, Eunhyun Ryu, Yu Su Shin, Jong Gwang Kim, Byung Woog Kang, Gi-Ho Sung, Hyosun Cho and Hyojeung Kang)
  • Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease (Fei-Yan Fan, Li-Xuan Sang and Min Jiang)
  • A Review of the Antiviral Role of Green Tea Catechins (Jun Xu, Zhao Xu and Wenming Zheng)

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